Speaking to Entertainment Weekly , MacFarlane - who worked for Hanna-Barbera prior to Family Guy - wanted to be a Disney animator until he saw The Simpsons.
© PA Images / Dan Steinberg/AP/Press Association Images
"[Matt Groening's] show redirected the course of where I wanted my professional life to go," MacFarlane revealed.
"I wanted to be a Disney animator, and then The Simpsons came out, and in every way - writing-wise, production-wise, timing-wise, animation-wise - it just rewrote the rulebook.
"Suddenly I was laughing out loud at cartoons.
"I was doing stand-up at the time and I loved it, and I thought, 'It's too bad there isn't a way to do adult humour in cartoons'. And they just opened that door for everybody.
"That show came out and I remember thinking, 'Oh my god, this is what I want to do'. It's like All in the Family. It's that degree of altering the landscape."
Speaking alongside The Simpsons creator Matt Groening, the pair were also asked which characters they would like to steal from each other's shows.
Groening said: "Well, I'm really jealous of the chicken - the whole chicken fight thing. But I guess Stewie. Just comedy gold."
MacFarlane said that Mr Burns was a character that had always amused him, before revealing that the character had partly influenced Stewie.
"Stewie comes from Rex Harrison first and foremost, but I would be lying [if I said] there wasn't a shred of Mr Burns's influence.
"He was just always a character that got a nice big laugh out of me when he emerged and throughout his run.
"If I couldn't have Mr Burns, I'd take Leonard Nimoy," he added.
The Simpsons and Family Guy crossover episode airs on September 28 in the US.
The episode was recently criticised by the Parents Television Council for featuring a joke about rape.
Watch the full trailer for 'The Simpsons Guy' below:
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via All - Digital Spy - Entertainment and Media News
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