When we heard the news that Sandra Oh is leaving "Grey's Anatomy" after the upcoming 10th season, we immediately thought about Cristina Yang's best moments. Most of them, obviously, are with her person, Meredith Grey (Ellen Pompeo), which makes it sting even more.


Sadly, the feeling isn't unfamiliar -- we felt the same sting a few weeks ago when NBC announced that Rashida Jones will be leaving "Parks and Recreation" this season. So now we'll be losing two of TV's best female duos in one year.


Mer without Cristina? Leslie without Ann? What is TV female best friendship coming to? Who will dance it out, tell each other they're beautiful and repeatedly reassure each other that they are, in fact, their person? Check out our mash-up, above, which honors these fabulous, flawed and funny TV friendships.


Video edited by Amber Genuske.



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  • Ellen DeGeneres




  • Linda Smith




  • Nora Ephron




  • Rebecca Front




  • Jo Brand




  • Wanda Sykes




  • Maria Bamford




  • Carol Burnett




  • Sarah Silverman




  • Jane Austen




  • Joan Rivers




  • Tina Fey




  • Phyllis Diller




  • Lucille Ball




  • Victoria Wood




  • Jennifer Saunders




  • Sarah Millican




  • Watson And Oliver




  • Roseanne Barr




  • Joanna Scanlan




  • Sara Pascoe




  • Rita Rudner




  • Zsa Zsa Gabor




  • Gilda Radner




  • Dawn French




  • Jo Caulfield




  • Megan Amran




  • Lucy Porter




  • Amy Poehler




  • Richmal Crompton




  • Kristen Schaal




  • Bridget Christie




  • Garfunkel And Oates




  • Marti Caine




  • Valerie Harper




  • Miranda Hart




  • Stella Gibbons




  • Vicki Pepperdine




  • Kathy Lette




  • Tig Notaro




  • Kristen Wiig




  • Ashley Jensen




  • Anna And Katy




  • Luisa Omielan




  • Tracey Ullman




  • Aubrey Plaza




  • Joanna Lumley




  • Lily Tomlin




  • Megan Mullally




  • Sandi Toksvig




  • Julie Klausner