The actress, who plays Dr Cristina Yang, will depart at the end of the new season after ten years in the role.
She said in a statement to The Hollywood Reporter : "Creatively, I really feel like I gave it my all, and I feel ready to let her go.
"It's such an interesting thing to play a character for so long and to actually get the sense that she wants to be let go as well. [Cristina] wants to be let go, and I am ready to let her go.
"We have to start the process, story-wise, for the Grey's writers to think of why she's going to go."
Grey's creator Shonda Rimes added: "One of the best days of my life as a writer happened the day Sandra Oh walked in my door to audition and forever changed the course of Grey's Anatomy with her brilliant, nuanced portrayal of Cristina Yang.
"Over the past ten seasons, I have been made better by Sandra's trust, faith and friendship and I can't quantify how grateful I am for her collaboration on a character we both love so deeply. This year is going to be bittersweet for us - we're both going to savor every moment of Cristina Yang and then we're going to give her the exit she deserves.
"And when Sandra walks out of my door, Grey's Anatomy will once again be forever changed."
ABC president Paul Lee recently said that Grey's Anatomy can go on "for many, many years to come".
The tenth season of Grey's Anatomy begins on September 26 in the US.
Watch a promo for the Grey's Anatomy ninth season finale below:
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via All - Digital Spy - Entertainment and Media News
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